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Table 1 Average absolute value of severity associations for the SNPs within eight candidate genes.

From: Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome

Gene Name

Gene Location

Average Correlation (SD)

Count of SNPs in candidate gene

Most Correlated SNP

    

Name

Correlation

p-value

POMC

2p24

0.14 (NA)

1

rs12473543

0.135

0.216

NR3C1

5q34

0.07 (0.06)

7

rs258750

0.198

0.069

CRHR2

7p15

0.15 (0.08)

3

hCV15960586

0.225

0.036

TH

11p15

0.07 (0.01)

2

rs4074905

0.080

0.466

TPH2

12q21

0.23 (0.04)

7

rs10784941

0.275

0.010

SLC6A4

17q11.1

0.18 (0.17)

3

rs4325622

0.347

0.001

CRHR1

17q21

0.03 (0.02)

6

rs242940

0.069

0.531

COMT

22q11.1

0.04 (0.02)

7

hCV11804654

0.077

0.479

  1. TPH2 with seven SNPs had the highest average association with CFS severity.