Hub classifier | Â | Â | Â | Â | Â | Â | Â |
---|---|---|---|---|---|---|---|
observed | predicted non-hub | predicted hub | sensitivity | specificity | accuracy | PPV | NPV |
non-hub | 109 | 11 | 30.77% | 90.83% | 84.96% | 26.67% | 92.37% |
hub | 9 | 4 | Â | Â | Â | Â | Â |
Hypothetical PIN – pathway maps | |||||||
observed | predicted non-hub | predicted hub | sensitivity | specificity | accuracy | PPV | NPV |
non-hub | 111 | 9 | 0.00% | 92.50% | 83.46% | 0.00% | 89.52% |
hub | 13 | 0 | Â | Â | Â | Â | Â |
Hypothetical PIN – orthologous interactions | |||||||
observed | predicted non-hub | predicted hub | sensitivity | specificity | accuracy | PPV | NPV |
non-hub | 110 | 10 | 23.08% | 91.67% | 84.96% | 23.08% | 91.67% |
hub | 10 | 3 | Â | Â | Â | Â | Â |
Hypothetical PIN – interacting domains | |||||||
observed | predicted non-hub | predicted hub | sensitivity | specificity | accuracy | PPV | NPV |
non-hub | 117 | 3 | 0.00% | 97.50% | 87.97% | 0.00% | 90.00% |
hub | 13 | 0 | Â | Â | Â | Â | Â |
Combined hypothetical PIN – (pathway maps + orthologous interactions) | |||||||
observed | predicted non-hub | predicted hub | sensitivity | specificity | accuracy | PPV | NPV |
non-hub | 110 | 10 | 23.08% | 91.67% | 84.96% | 23.08% | 91.67% |
hub | 10 | 3 | Â | Â | Â | Â | Â |
Combined hypothetical PIN – (pathway maps + orthologous interactions + interacting domains) | |||||||
observed | predicted non-hub | predicted hub | sensitivity | specificity | accuracy | PPV | NPV |
non-hub | 108 | 12 | 7.69% | 90.00% | 81.95% | 7.69% | 90.00% |
hub | 12 | 1 | Â | Â | Â | Â | Â |