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Table 4 Geometric parameters for the breast tumor

From: A compartment model of VEGF distribution in blood, healthy and diseased tissues

 

Value

Unit

Reference

Cancer cells

   

Tumor cells external diameter

17

μ m

[43]

Volume of one cell

2572

μ m3

[4]

Surface area of one cell

997

μ m2

[4]

Microvessels

   

Average luminal diameter

10.3

μ m

[44, 45]

Endothelial cell thickness

0.5

μ m

[4]

Average external diameter

11.3

μ m

[4]

Cross sectional area of one vessel

100.3

μ m2

[4]

Perimeter of one vessel

43.7

μ m

[4]

Volume fractions

   

Interstitial space

61.1%

cm3/cm3 tissue

[46, 47]

Cancer cells

37%

cm3/cm3 tissue

[4]

Microvessels

2.4%

cm3/cm3 tissue

[4]

   of which intravascular space

2%

 

[4]

Surface areas

   

Tumor cells

1416

cm2/cm3 tissue

[4]

Microvessels

105

cm2/cm3 tissue

[4]

Basement membranes (BM)

   

Thickness of tumor cell BM

30

nm

[4]

Basement membrane volume (tumor cells)

0.00388

cm3/cm3 tissue

Calculated

   of which available to VEGF

0.002446

cm3/cm3 tissue

Calculated

Thickness of microvessel BM

50

nm

[4]

Basement membrane volume (microvessels)

0.00043

cm3/cm3 tissue

Calculated

   of which available to VEGF

0.000270

cm3/cm3 tissue

Calculated

Extracellular matrix volume

0.6062

cm3/cm3 tissue

Calculated

   of which available to VEGF

0.519308

cm3/cm3 tissue

Calculated