Table 1 Geometric parameters for the healthy tissue (human vastus lateralis muscle)

Muscle fibers

Cross sectional area of one fiber

3000

μ m²

[6]

Perimeter of one fiber

222

μ m

[6]

Capillary-fiber ratio

1.38

[37]

Capillary density

420

capillaries/mm² tissue

[6]

Muscle fiber density

304

fibers/mm² tissue

[6]

Volume fractions

Interstitial space

8.16%

cm³/cm³ tissue

[38, 39]

Fibers

89.98%

cm³/cm³ tissue

[6]

Microvessels

1.86%

cm³/cm³ tissue

[6]

   of which vascular space

1.4%

cm³/cm³ tissue

[40]

Microvessels

Internal diameter of microvessel

6.56

μ m

[6]

Thickness of endothelial cell

0.5

μ m

[41]

External diameter of microvessel

7.56

μ m

[6]

Cross sectional area of one microvessel

45

μ m²

[6]

Perimeter of one microvessel

26

μ m

[6]

Surface areas

Muscle fibers

664

cm²/cm³ tissue

[6]

Microvessels

108

cm²/cm³ tissue

[6]

Basement membranes (BM)

Thickness of muscle fiber BM

24

nm

[42]

Basement membrane volume (muscle fiber)

0.00159

cm³/cm³ tissue

Calculated

   of which available to VEGF

0.000307

cm³/cm³ tissue

Calculated

Thickness of microvessel BM

43

nm

[42]

Basement membrane volume (microvessel)

0.00045

cm³/cm³ tissue

Calculated

   of which available to VEGF

0.000087

cm³/cm³ tissue

Calculated

Extracellular matrix volume

0.07951

cm³/cm³ tissue

Calculated

   of which available to VEGF

0.061987

cm³/cm³ tissue

Calculated

Skeletal muscle nuclear domain (SMND) surface area

1850

μ m²

[6]