Table 2 Target genes that shRNA were significantly enriched.
From: Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion
Gene | P-value | T-statistics | Entrez Gene | Significant GO term | GO category | shRNA sequence |
|---|---|---|---|---|---|---|
EDN2 | 0.0011 | 20.9528 | 1907 | transmembrane receptor protein tyrosine kinase signaling pathway | BP | 5'AGCTCTGCTGGAAGA ACTGCATGGGGA3' |
ARNTL2 | 0.0020 | 15.7851 | 56938 | transcription factor activity | MF | 5'TTACCTTGTAGCTCT CAATCATCAGAA3' |
ZNF232 | 0.0030 | 12.7514 | 7775 | transcription factor activity | MF | 5'TATAACTCACATCT TGTTGTCCACCAG3' |
ADH5 | 0.0040 | 11.1071 | 128 | ethanol oxidation | BP | 5'GTATAACCTAAACC ATCTACTCTTTAG3' |
COL15A1 | 0.0043 | 10.7380 | 1306 | extracellular matrix (sensu Metazoa) | CC | 5'GCAACTGCTGTTCGT ACACAGAAACAG3' |
EMP3 | 0.0071 | 8.2852 | 2014 | negative regulation of cell proliferation | BP | 5'TGAATCTCTGGTACG ACTGCACGTGGA3' |
MYT2 | 0.0072 | 8.2309 | 8827 | transcription factor activity | MF | 5'AAGCAGATGATATT CCAGACGGTATTA3' |
ZNF219 | 0.0079 | 7.8689 | 51222 | transcription factor activity | MF | 5'GGTAGTGGGCCCTCA GGGGCGATTAGC3' |
IL6ST | 0.0080 | 7.8232 | 3572 | oncostatin-M receptor activity | MF | 5'TGTCCAGTATTCTAC CGTGGTACACAG3' |
MEOX2 | 0.0080 | 7.8013 | 4223 | transcription factor activity | MF | 5'GCACTCACAATGACA ACCAGAGCCAGT3' |
EPHB4 | 0.0092 | 7.2683 | 2050 | transmembrane receptor protein tyrosine kinase signaling pathway | BP | 5'TTCTACCGTCCTTGT CATAACTTTGTG3' |
KLF10 | 0.0093 | 7.2104 | 7071 | negative regulation of cell proliferation; transcription factor activity | BP/MF | 5'ATTGGGTGTAGATTT CTGACATCAAAA3' |
TFEC | 0.0097 | 7.0622 | 22797 | transcription factor activity | MF | 5'GCTATGCAATTATGC TCTGTGTTTCAT3' |
NPC1 | 0.0098 | 7.0363 | 4864 | sterol transporter activity | MF | 5'GATGCTCTCATAAGG CCCAGGAAGGAT3' |