Figure 8From: Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approachpH dependence of Ca2+ binding to CaM. Ca2+ binding to CaM under different pH conditions measured by [9] can be explained in terms of altered dissociation and cooperative dissociation constants. The increase of pH raises affinity to Ca2+ and eliminates cooperativity between Ca2+ binding sites on CaM.Back to article page