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Table 4 Ten most central proteins in the fPIN.

From: The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles

Protein

RB

BN

DC

Protein description

ATP14

17.17

25.44 (1)

5.14 (14)

ATP synthase H chain, mitochondrial

FBA1

11.34

6.71 (6)

4.45 (20)

Fructose-bisphosphate aldolase

TSC13

8.49

10.28 (3)

3.07 (33)

Enoyl reductase, very long fatty acid elongation

IFA38

7.73

1.26 (37)

8.59 (4)

Oxidoreductase, fatty acid elongation

COX1

7.69

4.43 (14)

5.14 (15)

Cytochrome c oxidase subunit 1

SER3

7.49

-0.32 (1449)

5.83 (8)

D-3-phosphoglycerate dehydrogenase 1

COX5B

7.19

3.53 (17)

1.00 (117)

Cytochrome c oxidase polypeptide Vb, mitochondrial [Precursor]

URA2

6.74

2.72 (21)

3.07 (31)

Bifunctional glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyl-transferase

GPM1

6.60

2.94 (20)

2.38 (42)

Phosphoglycerate mutase 1

MAE1

6.46

9.46 (4)

0.31 (160)

NAD-dependent malic enzyme, mitochondrial [Precursor]

  1. Ten most central proteins in the fPIN as judged by the z-score of the change of the characteristic length of the graph after removal of a particular protein, robustness centrality (RB). For comparison to other centrality measures, the z-scores and respective rank (in parentheses) of the betweenness centrality (BN) as well as degree centrality (DC) were evaluated. The overall correlation between the centrality was RB~BN 0.70 (p-Value: 4.35E-220), RB~DC 0.59 (p-Value: 1.44E-144) and BN~DC 0.25 (p-Value 3.37E-23)