Figure 7

Crosstalk via protein interactions between enzymes and proteins in A) glycolysis and the respiratory chain (ubiquinol cytochrome-c reductase complex (Complex III); cytochrome c oxidase (Complex IV) and ATP synthase (Complex V)) as well as B) systems for biosynthesis of membrane lipids (biosynthetic systems for sphingolipids, fatty acid, steroids as well as for phosphatidylcholine). Individual proteins are highlighted in blue. If belonging to the group of 10 most central proteins of the fPIN (see Table 4), they are colored red. Boxes with dashed perimeter indicate larger metabolic systems. Touching protein boxes indicate interaction between the proteins, whereas protein boxes emerging from metabolic system denote participation of that protein in this system. ARE2: Acyl-CoA:sterol acyltransferase; ATP14: H chain of ATP synthase; CHO1: phosphatidylserine synthase; Cox5b and Cox1: Subunit Vb and I of cytochrome c oxidase; CPT1: Cholinephosphotransferase; EPT1: sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; ERG25: C-4 methyl sterol oxidase; ERG3: C-5 sterol desaturase; FAS1: Beta subunit of the fatty acid synthase; FBA1: Aldolase; FEN1: Fatty acid elongase, involved in sphingolipid biosynthesis; GPM1: phosphoglycerate mutase; HMG1: HMG-CoA reductase; IFA38: oxidoreductase, fatty acids elongation; LAC1: Ceramide synthase; MDM38: required for k+/H+ exchange; OLE1: Delta(9) fatty acid desaturase; QCR8: Subunit 8 of ubiquinol cytochrome-c reductase complex; Sur2: Sphinganine C4-hydroxylase; TSC13: enoyl reductase, very long fatty acids elongation; YDC1: Alkaline dihydroceramidase, sphingollipids metabolism;