Figure 3

Screen-shot of the application. The upper left part shows KEGG-data as a graphical tree. The tree node of the reaction R00149 is expanded. The traffic light icon indicates that this reaction node has at least one dataset. The sub-nodes of R00149 contain information on the EC-number 6.3.4.16, the biochemical pathway maps where this reaction is contained, the four substrates and three reaction products, the ENSEMBL entry ENSG00000021826 and the three SWISSPROT entries. The lower left panel contains the textural description of the reaction. Words with a blue frame act as hyperlinks. The right part shows datasets for the two carbamoylphosphate synthetases R00149 and R00575 and the transport of citrulline across the inner mitochondrial membrane. The biochemical equation for R00149 and R00575 were taken from KEGG and the equation for the transport process was entered manually. The red arrow in R00575 indicates that there is a slight error in the equation. The left side of the equation has an hydrogen less than the right side. This can be corrected by adding " + H+" into the equation. The "H+" will automatically be replaced by "C00080". One can also use the button [compound] to select hydrogen from a list of compounds.