Figure 7

Predictions of the multiscale model. (Top Row) Screenshots from the multiscale model at different simulation time points show that cells migrate in a uniform direction while maintaining contact with one another. (Bottom Row) As cells migrate toward the top of the simulation space, a Fn matrix gradient is established from the leading edge to trailing edge of the mesendoderm explant, and this can also be seen in the darkening of pixels behind migrating cells.