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Table 5b Detailed listing of the AL results for the False Negative results for iNJ 661. The first column lists a locus needed for optimal growth according to the OptGro dataset. The second column lists the reactions involved. The third column lists the possible alternative loci in iNJ 661 (commas indicate isozymes, addition symbols indicate formation of protein complexes).

From: Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ 661 and proposing alternative drug targets

Alternative Loci in False Negative results

OptGro

Reaction

Other loci in iNJ661

Rv0337c

ASPTA

Rv2565

Rv0462

PDHc, PDH, PDHa

Rv0843, Rv2497c+Rv2496c

Rv0808

GLUPRT

Rv1602

Rv0824c

DESAT18

Rv1094

Rv1122

GND

Rv1844c

Rv1600

HSTPT

Rv3772, Rv2231c

Rv1602

GLUPRT

Rv0808

Rv1609

ANS

Rv2859c

Rv2182c

AGPAT160190, AGPAT160, AGPAT190

Rv2483c

Rv2215

PDH, AKGDb

Rv2241, Rv0462, Rv0843

Rv2231c

HSTPT

Rv1600, Rv3772

Rv2397c

SULabc, TSULabc

Rv1739c

Rv2398c

SULabc, TSULabc

Rv1739c

Rv2399c

SULabc, TSULabc

Rv1739c

Rv2400c

SULabc, TSULabc

Rv1739c

Rv2682c

DXPS

Rv3379c

Rv2746c

PGSA190, PGSA160, PGSA160190

Rv1822

Rv2996c

PGCD

Rv0728c

Rv3003c

ACLS

Rv3509c+Rv3002c, Rv1820+Rv3002c, Rv3509c+Rv3002c, Rv3002c+Rv3470c

Rv3042c

PSP_L

Rv0505c

Rv3257c

PMANM, AIRCr

Rv3275c+Rv3276c

Rv3275c

AIRCr

Rv3257c+Rv3276c

Rv3281

ACCOACr

Rv3280+Rv0904c

Rv3441c

PMANM, ACGAMPM

Rv3308, Rv3257c

Rv3634c

UDPG4E

Rv0536, Rv0501

Rv0112

GMAND

Rv1511

Rv2247

PPCOAC

Rv2502c+Rv0973c, Rv3285+Rv0974c, Rv0973c+Rv0974c,

Rv0973c

PPCOAC

Rv2502c+Rv0973c, Rv3285+Rv0974c, Rv0973c+Rv0974c, Rv2501c+Rv2247

Rv3285

PPCOAC

Rv2502c+Rv0973c, Rv0973c+Rv0974c, Rv2501c+Rv2247

Rv2967c

PC

Rv2976c

Rv3464

TDPGDH

Rv3468c, Rv3784

Rv2754c

TMDS

Rv2764c

Rv3713

ADCYRS

Rv2848c